Placental hypoxia-regulating network in relation to birth weight and ponderal index: the ENVIRONAGE Birth Cohort Study
نویسندگان
چکیده
منابع مشابه
NEONATAL MORTALITY IN RELATION TO BIRTH WEIGHT
730 low birth weight (LBW) neonates and 1460 controls were selected from 13,123 neonates born from October 1988 to June 1989 in 17 hospitals and maternity units in Tehran, and were compared for mortality in the first seven and up to 28 days of life (early neonatal period). In this study all low birth weight newborns are divided according to four sub-groups of birth weight, and the mortalit...
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BACKGROUND Mitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction. OBJECTIVE We investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitro...
متن کاملPlacental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study
Most research to date has focused on epigenetic modifications in the nuclear genome, with little attention devoted to mitochondrial DNA (mtDNA). Placental mtDNA content has been shown to respond to environmental exposures that induce oxidative stress, including airborne particulate matter (PM). Damaged or non-functioning mitochondria are specifically degraded through mitophagy, exemplified by l...
متن کاملPolymorphisms in FTO and MAF Genes and Birth Weight, BMI, Ponderal Index, Weight Gain in a Large Cohort of Infants with a Birth Weight below 1500 Grams
BACKGROUND The FTO gene, located on chromosome 16q12.2, and the MAF gene, located on chromosome 16q22-23, were identified as genes harboring common variants with an impact on obesity predisposition. We studied the association of common variants with birth weight, gain of body weight, body mass index (BMI), Ponderal index and relevant neonatal outcomes in a large German cohort of infants with a ...
متن کاملBirth weight and lipids in a national birth cohort study.
OBJECTIVE To investigate the association between birth weight and lipid levels in a 53-year-old birth cohort from England, Scotland, and Wales. METHODS AND RESULTS Lipid levels were obtained from nonfasting blood samples, collected at the most recent follow-up of the MRC National Survey of Health and Development, for 2559 men and women. Regression models indicated that in men, a 1-kg increase...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2018
ISSN: 1479-5876
DOI: 10.1186/s12967-017-1375-5